Endocrine Abstracts

Androgen therapy is the mainstay of treatment in female to male (FtM) transgender persons to increase testosterone levels, suppress oestrogens and treat gender dysphoria. Testosterone is widely used for male hypogonadism, but is comparatively under-investigated in FtM transgender persons. The aim of our study was to identify treatment and safety outcomes associated with testosterone use in transgender medicine. A literature search was conducted in PubMed/Medline, as well as EM...

Background: Hypogonadism is estimated to account for over 10% of male-factor infertility. However, due to conflicting data regarding the relationship between testosterone levels and sperm quality, hormone evaluation is not consistently requested during initial assessment of the infertile male. Hypogonadism is associated with cardiovascular disease (CVD) and has been linked to an increased risk of mortality The aim of this study was to investigate the prevalence of hypogonadism...

Introduction: Endocrine disrupting chemicals (EDC) are exogenous substances altering function(s) of the endocrine system. EDCs have been implicated in the decline in male reproductive health. We aimed to systematically review the pathophysiological effects of EDCs on male reproductive health.Methods: Searches of EMBASE, MEDLINE and PubMed were conducted using the following terms: ‘endocrine disrupt*’ OR ‘endocrine disruptors’ OR &#145...

Introduction: Selective oestrogen receptor modulators (SERMs) and aromatase inhibitors (AIs) potentially increase endogenous gonadotrophin and testosterone secretion in men. They are used off-label in men with hypogonadism and/or infertility. There is a lack of guidance on using these agents in men with secondary hypogonadism, though these agents are widely used in these people as a cheaper alternative to gonadotrophins. Methods: Systematic search was co...

Background: Since the preliminary epidemiological data concerning the coronavirus disease 2019 (COVID-19) has been availabe, clear sex disparity has been evident, with males, although not more frequently affected, often experiencing worse outcomes when compared to women. The short and long term andrological effects of coronavirus disease 2019 (COVID-19) have not been clarified. The aim of the present study is to systematically review and meta-analyze all available data regardi...